{"id":6297,"date":"2022-07-25T02:53:16","date_gmt":"2022-07-25T02:53:16","guid":{"rendered":"https:\/\/dailyhealthybox.com\/2022\/07\/25\/study-finds-alzheimers-compromises-the-immune-system-as-well-as-the-brain-offering-insights-on-brain-body-communication\/"},"modified":"2022-07-25T02:53:16","modified_gmt":"2022-07-25T02:53:16","slug":"study-finds-alzheimers-compromises-the-immune-system-as-well-as-the-brain-offering-insights-on-brain-body-communication","status":"publish","type":"post","link":"https:\/\/www.healthoptibody.com\/?p=6297","title":{"rendered":"Study finds Alzheimer\u2019s compromises the immune system as well as the brain, offering insights on brain-body communication"},"content":{"rendered":"<p><!-- - --><\/p>\n<p><img decoding=\"async\" style=\"max-width:1000px;width:100%\" border=\"0\" src=\"http:\/\/demo2.tadke.com\/health-news-s\/uploads\/health-news-s0423\/Senior-Man-Hands-Scalp-Brain1878.jpg\"><\/p>\n<p><!-- - --><\/p>\n<hr class=\"Marker\" id=\"Marker2\">\n<p><!-- @page { margin: 0.79in } P { margin-bottom: 0.08in } A:link { so-language: zxx } --><\/p>\n<p>A new study published in the <i>Journal of Alzheimer&#8217;s Disease<\/i> provides new information on how the brain and the rest of the body communicate.<\/p>\n<ul>\n<li>Previous studies have suggested that pathology related to Alzheimer&#8217;s disease may occur before the clinical symptoms of the disease manifest, and that inflammation is one of the main components of the disease.<\/li>\n<li>Links between the levels of inflammatory markers in cerebrospinal fluid and blood, and mild cognitive impairment, have also been revealed in past research.<\/li>\n<li>Moreover, scientists have discovered that increases in inflammatory markers may appear even decades before any symptoms of Alzheimer&#8217;s disease appear.<\/li>\n<li>The researchers of the current study wanted to determine whether these inflammation markers in the blood were related to known measures of Alzheimer&#8217;s-related pathology, even after considering cerebrospinal fluid levels of inflammation.<\/li>\n<li>Moreover, they aimed to identify whether inflammation markers in blood plasma indicated inflammation of the central nervous system.<\/li>\n<li>They examined blood and cerebrospinal fluid samples from 173 middle-aged and older adults who enrolled in the <em>Wisconsin Alzheimer&#8217;s Disease Research Center<\/em>. The participants were all healthy and had no clinical symptoms of Alzheimer&#8217;s, but some had family histories of dementia believed due to Alzheimer&#8217;s.<\/li>\n<li>Results showed that both plasma and cerebrospinal fluid markers of inflammation independently sent information about Alzheimer&#8217;s-related pathology and neuronal damage.<\/li>\n<li>The study was carried out by a group of researchers from the <i>University of Colorado Anschutz Medical Campus<\/i>, together with the <i>University of Wisconsin Alzheimer&#8217;s Disease Research Center\u00a0<\/i>and the <i>University of California San Francisco Memory and Aging Center<\/i>.<\/li>\n<\/ul>\n<p>Overall, the study suggests that there is a link between inflammation biomarkers in both plasma and cerebrospinal fluid and markers of Alzheimer&#8217;s disease associated pathology.<\/p>\n<\/p>\n<p>Journal Reference:<\/p>\n<p>Bettcher, B., Johnson, S., Fitch, R., Casaletto, K., Heffernan, K., Asthana, S., Zetterberg, H., Blennow, K., Carlsson, C., Neuhaus, J., Bendlin, B., Kramer, J. CEREBROSPINAL FLUID AND PLASMA LEVELS OF INFLAMMATION DIFFERENTIALLY RELATE TO CNS MARKERS OF ALZHEIMER\u2019S DISEASE PATHOLOGY AND NEURONAL DAMAGE. Journal of Alzheimer&#8217;s Disease, 2018; 62 (1): 385 DOI: http:\/\/dx.doi.org\/10.3233\/JAD-170602<\/p>\n<p><!-- - --><\/p>\n<p>\n","protected":false},"excerpt":{"rendered":"<p>A new study published in the Journal of Alzheimer&#8217;s Disease provides new information on how the brain and the rest of the body communicate. Previous studies have suggested that pathology related to Alzheimer&#8217;s disease may occur before the clinical symptoms of the disease manifest, and that inflammation is one of the main components of the<\/p>\n","protected":false},"author":1,"featured_media":6298,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987],"tags":[563,1001,34,68],"class_list":{"0":"post-6297","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-healthy-living","8":"tag-alzheimer","9":"tag-compromises","10":"tag-immune","11":"tag-study"},"_links":{"self":[{"href":"https:\/\/www.healthoptibody.com\/index.php?rest_route=\/wp\/v2\/posts\/6297","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.healthoptibody.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.healthoptibody.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.healthoptibody.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.healthoptibody.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6297"}],"version-history":[{"count":0,"href":"https:\/\/www.healthoptibody.com\/index.php?rest_route=\/wp\/v2\/posts\/6297\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.healthoptibody.com\/index.php?rest_route=\/wp\/v2\/media\/6298"}],"wp:attachment":[{"href":"https:\/\/www.healthoptibody.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6297"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.healthoptibody.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6297"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.healthoptibody.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6297"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}